Project Enthral

Project Enthral

The main objective of the project is to develop a non invasive technique of assessing the stiffness of the carotid arthery. This will be achieved through originally designed experriments and advanced numerical simulations executed by a team of engineers representing various disciplines and supported by medical doctors.

The project objectives
are defined as:

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Development of a method for estimating local material properties of arterial walls from non-invasive in-vivo measurements

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Development of 3D numerical model of blood flow within a deforming vessel

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Validation of the model using a test rig
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Comparison with existing 1D model developed by NTNU

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Inverse analysis aimed at retrieving the stiffness of the vessel
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Application of the developed methodology to retrieving the stiffness of the carotid artery

Stiffness of arteries wall
- subject background

With aging there is a noticeable increase in the stiffness of arteries. Arteries tend to accumulate less elastic potential energy as stiffness increases, they are less elastic. Heart is forced to overperform to compensate for the decreased outflow from arteries, which leads to left ventricular hypertrophy. Amplified pressure waves leaving the heart are reaching very fine tissues located in kidneys or the brain, leading to their potential destruction.

Pulse pressure and wave reflection

Increasing arterial stiffness leads to a change in the behaviour of the reflected wave. The reflected wave returns to the heart at a shorter time then in healthy subjects.

Young
- small stiffness
Older adult
- increased stiffness

vanVarik BJ, Rennenberg RJMW, Reutelingsperger CP, Kroon AA, deLeeuw PW and Schurgers LJ (2012) Mechanisms of arterial remodeling: lessons from genetic diseases. Front.Gene. 3:290

This return usually collides with systole which leads to superposition of the reflected and outgoing wave yelding higher pressure than in healthy subjects. Such reinforced waves also make their way to delicate organs potentially causing damage.

Left Common Carotid Artery

The left common carotid artery is the longest branch of the aortic arch. It is a large and elastic channel that arises in the thorax from the arch of the aorta. It can be used to measure the pulse.

Why it matters?

Some cardiovascular diseases may locally change the stiffness of the arteries – a stronger spatial variation in the distensibility of the carotid has been shown in hypertensive patients compared to healthy subject.

Although the changes in the stiffness of the vascular system with age affect the whole vasculature, arteries at different sites respond differently to aging, hypertension, and pregnancy.

Methods of non-invasive evaluation of the local stiffness are often of interest in diagnostics of the arterial system.

Therefore, assessment of the stiffness of the arterial system is a valuable diagnostic index, it serves as a predictor of cardiovascular diseases.

Young adult
- compliant artery
Older adult
- stiff artery

 

6 working packages

Project has been divided into 6 work packages (WPs):

WP 1 Physical experiment 

Wojciech Adamczyk, PhD, DSc

WP 2 Direct models (1D STARFiSh and 3D CFD), comparison of solutions 

Ziemowit Ostrowski, PhD, DSc

WP 3 Validation, sensitivity analysis and uncertainty quantification

Jacob Sturdy, PhD

WP 4 Inverse analysis applied to the results of the physical experiment

Prof. Ryszard Białecki

WP 5 Medical experiment

Adam Golda, MD

WP 6 Inverse analysis of medical data

Prof. Leif Rune Hellevik

WP 1


Physical
experiment 

WP lead:

  • Experimental rig (phantom)
  • Physical experiment

WP 3


Validation

WP lead:

  • Uncertainly quantification
  • Validation
  • Sensivity analysis

WP 5


Medical
experiment

WP lead:

  • Medical experiment

WP 4

Inverse analysis

WP lead:

  • Inverse solution
  • Phantom experiment generated data

WP 2


Lab
models

WP lead:

  • Development of 1D and 3D FSI model

WP 6


Inverse analysis of medical data

WP lead:

  •  Inverse solution 
  • Medical data

Combined efforts

The experiments concerning the stiffness of the deformable artery imitation will be accompanied by an extensive numerical analysis involving methods used in inverse problems.

The numerical procedure will be built using data collected from the experiments and it will be subsequently used to obtain a reduced-order model that will try to recapture the complexity of the artery’s behaviour, while remaining computationally cost-efficient.

Flowmeters

1 of 7

Fast pressure sensors

2 of 7

Deformable material

3 of 7

Fast cameras

4 of 7

Fast cameras

5 of 7

Flowmeters

6 of 7

Capacitor

7 of 7

Simplified scheme
of the experimental rig

Experimental site will be prepared in the form of an aquarium filled with ballistic gel.

Project tests phase - medical experiment

The final stage of the project will involve USG measurements performed on live subjects (healthy volunteers) that will be carried out in Gliwice Municipal Hospital Number 4 under supervision of Adam Golda, M.D.

More about us

Our cooperation was possible thanks to Norway grants which funded 85% of project budget and to Polish government which supported project by funding 15% of total budget.

Thanks to them, it was possible for us to arrange our consortium which is combination of some very talented and highly specialised crews from:

Project Promoter:
Silesian University of Technology (SUT)

Department of Thermal Technology
Department of Thermal Technology Biomedical Engineering Lab
Department of Informatics and Medical Devices
Department of Biomechatronics
Department of Biomaterials and Medical Device Engineering

Consortium

Norwegian University of Science and Technology (NTNU)

Division of Biomechanics

Gliwice Municipal Hospital No 4 (GMH)

Department of Cardiologye and Technology (NTNU) 

Enthral project schedule and budget

36 months

October 1st, 2020 – September 30th, 2023

Total budget granted

0 PLN

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0

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